Overview

The cardinal goal of Dr. SanGiovanni's project is to determine whether lipid-sensing complexes interacting with molecular targets in dopamine-based signaling cascades may be appreciably modulated by exposure to essential, brain-resident nutrients or their metabolites – and, if so, whether such effects have value for explaining resilience or informing development of preventive or therapeutic interventions during periods of vulnerability.

Wednesday, September 30, 2015

Developmental Neurobiology -- Cecilia Flores @ McGill

Cecilia Flores is an expert on the devleopmental neurobiology of a family of neural guidance molecules, the netrins and their receptors.  She has extensive experience in applying multidisciplinary approaches for examining the role of these molecules as modulators of dopmaine signaling system structure and function at the micro-environmental (genes, molecules, gene products acting as constituents of signaling pathways), brain systems (cells, cell-cell complexes, cellular networks), and external environmental (Rx exposure) levels.  Much of Cecilia's work has answered key questions on resilience and vulnerability (involving brain development and in neuroplasticity in the adult brain brought about by exposure to stimulant drugs).  Research projects at the The Flores Laboratory are focused on neurodevelopmental studies, resilience, drugs and adolescent development, and adult plasticity.

John Paul and Cecilia have been in contact since the summer of 2015 regarding a collaboration on their aligned reseach interest in the NTN1-DCC-UNC5 axis in dopamine signaling. 

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