Overview

The cardinal goal of Dr. SanGiovanni's project is to determine whether lipid-sensing complexes interacting with molecular targets in dopamine-based signaling cascades may be appreciably modulated by exposure to essential, brain-resident nutrients or their metabolites – and, if so, whether such effects have value for explaining resilience or informing development of preventive or therapeutic interventions during periods of vulnerability.

Wednesday, September 30, 2015

Biostatistics & Enrichment Analysis -- Phil Hyoun Lee @ Harvard

Phil Hyoun Lee has extensive expertise in computational genetics and is the creator of INRICH, a pathway analysis tool for genome wide association studies that was designed for detecting enriched association signals of LD-independent genomic regions within biologically relevant gene sets. Phil holds a faculty appointment in the Psychiatric and Neurodevelopmental Genetics Unit in the Center for Human Genetic Research at Massachusetts General Hospital.  She has been a central contributor to a number of reports published by the Psychiatric Genomics Consortium on SZ and the consequences of dysregulated dopamine signaling. 

John Paul and Phil have collaborated closely on two systems-based projects leading to two publications.   One of these publications focused on the the NTN1-DCC, an interest of team member Cecilia Flores.  Phil has published on systems neuroscience with team member Neel Parikshak.
   


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